Ori · immune intelligence
The immune system is the missing layer in medicine.
We track the immune system over time to understand how disease begins and how to treat it.
Our belief
By dynamically programming the immune system, we can treat disease at its source.
How it works
We are building a deep, longitudinal dataset of the human immune system.
We follow the same people over time, tracking their immune markers, their medical records, and how they feel and live. Over time, they reveal how and why disease begins and progresses.
The immune system is the body's most powerful but least understood system. We're building the dataset and the model to finally understand it.
Where we start
We begin where the immune system has been overlooked.
Diseases the immune system drives, but no one has profiled. We start with Osteoarthritis and Endometriosis.
For doctors
A clearer view of immune-driven disease.
Together, we can understand how immune-mediated diseases begin, progress, and respond to treatment.
What partnering looks like
Profiling for your patients
Deep, longitudinal immune data on the patients you already treat, at no cost to you or them.
No burden on your practice
We handle consent, sampling, logistics, and follow-up.
Real clinical questions
Which immune signatures predict progression and treatment response, in diseases you see every week.
Build it with us
We build this with physicians, not around them. Help shape the questions and the tool, and see the findings first.
Access to the model
Partner with us and get access to our model, to query immune risk, trajectory, and likely treatment response for your patients.
It adds up to one thing: a better way to diagnose and treat your patients.
Partner with us →For patients
Your biology can move medicine forward.
There are diseases we still cannot cure, because medicine has never had the data to truly see them. The missing piece could be inside you.
These diseases have gone unmeasured for too long, and the people who live with them, unheard. Taking part changes that, for you and for everyone who comes after you.
Why take part
See your own biology
A clear view of your immune health over time, something no clinic offers today.
Help end the disease
Your data helps uncover how it begins, for you and everyone who comes after you.
Get paid
$500 for every sample you contribute.
How it works
One blood draw to start
One of our referring doctors writes your order, then you get a blood draw at any lab near you.
Connect your records
You securely connect your medical records, and we handle the rest.
Quarterly kit arrives
Every quarter, we mail a finger-prick kit to your door with everything you need.
Finger prick and survey
Do a quick finger prick and a short survey at home, in just a few minutes.
Mail it back and get paid
Mail it back with the prepaid label and packaging we include, and you are paid $500 for every sample.
It takes a few minutes each quarter, entirely from home. You're a partner in the science, not a data point.
Join the waitlist →Join the waitlist
Be first in line when we open enrollment.
Tell us a little about you. It takes under a minute and we'll reach out when a study opens that fits your profile, whether that's OA, endometriosis, or another condition.
Our mission
To understand the immune system.
So that we can dynamically predict and program it.
Most immune data is a single snapshot. Programs fail because the picture was never complete. Ori follows the same patients for years: deep immune measurement paired with real clinical and patient-reported context.
The immune system starts signaling long before symptoms emerge and a diagnosis is made. The earlier we capture patient-specific changes in that signal, the earlier programs can catch what matters.
Biomarker discovery
Find the signals that move with disease.
Target identification
Surface candidate drivers, not bystanders.
Stratification & trial enrichment
Match patients to the therapies they respond to.
Mechanistic insight
In indications no one has mapped as immune.
The model
On top of the data, we are building a predictive model of human immunology.
Our model is trained on data no one else has, so it learns how the immune system moves and predicts what it does next: who flares, who responds, and what drives the disease.
Every sample makes it better. Better predictions bring more patients and partners, and more data, so the model compounds.
Blog
Writing from Ori.
Our latest thinking on the immune system and where medicine is going.
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